Gata3 immunohistochemical staining is a useful marker for metastatic breast carcinoma in fine needle aspiration specimens

Gata3 immunohistochemical staining is a useful marker for metastatic breast carcinoma in fine needle aspiration specimens

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Aims: The utility of GATA3 immunohistochemistry (IHC) as an aid to the cytological diagnosis of metastatic breast carcinoma in fine needle aspiration cashel tail bag (FNA) specimens was investigated.Materials and Methods: Cell block sections from 111 FNA cases of metastatic malignancy were stained for GATA3, including metastases from 43 breast and 44 nonmammary adenocarcinomas, 19 melanomas, 4 urothelial carcinomas, and 1 thyroid medullary carcinoma.Sites sampled included lymph nodes (87), bone (8), liver (5), lung (6), superficial masses (4), and pelvic mass (1).Results: Ninety-one percent (39/43) of metastatic breast carcinoma cases were positive for GATA3.

All estrogen receptor (ER)-positive were also GATA3 positive cases.The majority (9/14; 64%) of ER-negative and 37% (3/8) of triple-negative cases were positive for GATA3.All nonmammary adenocarcinoma cases were negative with the exception of one case of metastatic pancreatic adenocarcinoma.Metastatic melanoma cases were read more all negative but 75% (3/4) urothelial carcinomas expressed GATA3.

Conclusions: GATA3 IHC staining is a useful addition to IHC panels for FNA samples in specific settings such as distinguishing metastatic breast from lung carcinoma or melanoma.